Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00056137" target="_blank" >RIV/00023001:_____/12:00056137 - isvavai.cz</a>

Result on the web

<a href="http://ac.els-cdn.com/S0304383512001048/1-s2.0-S0304383512001048-main.pdf?_tid=ba790cd225de29f1197aec431ab21a5b&acdnat=1340111606_878dd5d2b0f5b9ee244ef6de9f9fa512" target="_blank" >http://ac.els-cdn.com/S0304383512001048/1-s2.0-S0304383512001048-main.pdf?_tid=ba790cd225de29f1197aec431ab21a5b&acdnat=1340111606_878dd5d2b0f5b9ee244ef6de9f9fa512</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.canlet.2012.02.004" target="_blank" >10.1016/j.canlet.2012.02.004</a>

Result language

angličtina

Original language name

Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal

Original language description

Calcineurin inhibitors (CNIs) may promote post-transplantation cancer through altered expression of cytokines and chemokines in tumor cells. We found that there is a potential cross-talk among CNI-induced signaling molecules and mTOR. Here, we utilized amurine model of post-transplantation cancer to examine the effect of a combination therapy (CNI+mTOR-inhibitor rapamycin) on allograft survival and renal cancer progression. The therapy prolonged allograft survival; and significantly attenuated CNI-induced post-transplantation cancer progression, with down-regulation of mTOR and S6-kinase phosphorylation. Also, rapamycin inhibited CNI-induced over-expression of the angiogenic cytokine VEGF, and the chemokine receptor CXCR3 and its ligands in post-transplantation tumor tissues.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer letters

ISSN

0304-3835

e-ISSN

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Volume of the periodical

321

Issue of the periodical within the volume

2

Country of publishing house

IE - IRELAND

Number of pages

8

Pages from-to

179-186

UT code for WoS article

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EID of the result in the Scopus database

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