Variants within HNF1 alpha and ANGPTL4 genes and acute coronary syndrome in Czech population. The GENDEMIP study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00057937" target="_blank" >RIV/00023001:_____/12:00057937 - isvavai.cz</a>

Result on the web

<a href="http://www.nel.edu/home.htm" target="_blank" >http://www.nel.edu/home.htm</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Variants within HNF1 alpha and ANGPTL4 genes and acute coronary syndrome in Czech population. The GENDEMIP study

Original language description

BACKGROUND: Atherosclerosis is a complex arterial disease involving interactions between multiple genetic and environmental factors. A large number of genetic polymorphisms associated with atherosclerotic diseases have been identified in recent years. Weinvestigated the possible association between hepatic nuclear factor (HNF1-alpha) and angiopoietin-like 4 (ANGPTL4) single nucleotide polymorphisms and the risk of acute coronary syndrome (ACS) in the Czech population. MATERIALS AND METHODS: A total of1,182 patients with ACS (835 males and 347 females) and 1,200 healthy controls (827 males and 373 females) were included in the study. All patients were younger than 65 years of age. rs7310409 (A>G within the HNF1-alpha gene) and rs116843064 (G>A withinthe ANGPTL4 gene) were genotyped using TaqMan genotyping assays. RESULTS: The frequencies of the genotypes in patients with ACS did not significantly differ from the control group for the rs7310409 polymorphism (AA=17.1%, AG=46.6%, GG=36.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

suppl. 2

Country of publishing house

SE - SWEDEN

Number of pages

4

Pages from-to

13-16

UT code for WoS article

000312175400004

EID of the result in the Scopus database

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