Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909624" target="_blank" >RIV/00216208:11120/15:43909624 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/15:10295982 RIV/00064203:_____/15:10295982 RIV/00023001:_____/15:00059495 RIV/00064165:_____/15:10295982 RIV/00023884:_____/15:#0007163

Result on the web

<a href="http://dx.doi.org/10.1007/s11033-015-3870-1" target="_blank" >http://dx.doi.org/10.1007/s11033-015-3870-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11033-015-3870-1" target="_blank" >10.1007/s11033-015-3870-1</a>

Result language

angličtina

Original language name

Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome

Original language description

Myocardial infarction (MI) is the leading cause of death in industrialized countries. All the traditional risk factors for MI are responsible for approximately 50 % of cases of MI cases. Attention therefore has recently focused on genetic variants that are not associated with conventional risk factors. One of them is the marker rs6922269, which has been suggested as a risk factor for development of MI in Western populations. We analyzed the relationship between rs6922269 variant on MTHFD1L gene and (i) risk of the acute coronary syndrome (ACS) in the Czech population and (ii) mortality in 7 years follow up. Rs6922269 (G>A) variant was analyzed (CR 99.3 % for patients and 98.0 % for controls) by PCR-RFLP in consecutively examined 1614 men and 503 women with ACS (age below 65 years) and in population-based controls--1191 men and 1368 women (aged up to 65 years). ANOVA and Chi square were used for statistical analysis. The genotype frequencies were almost identical (P = 0.87) in the ACS patients and in controls and no differences were observed, if males (P = 0.73) and females (P = 0.93) were analysed separately. In addition, rs6922269 polymorphism was not associated with the classical risk factors (dyslipidemia, hypertension, obesity, smoking, diabetes) in control population. Cardiovascular mortality was significantly higher in males, carriers of the AA genotype (P < 0.001, OR 2.52, 95 % CI 1.40-4.55, for AA vs. +G). We conclude, that rs6922269 variant at MTHFD1L gene could be an important prognostic factor for cardiovascular mortality in patients after ACS.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

<a href="/en/project/NT12217" target="_blank" >NT12217: Genetic factors determining the risk of atherothrombotic vascular events in patients without classical risk factors of atherosclerosis and in patients treated with a statin.</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Biology Reports

ISSN

0301-4851

e-ISSN

—

Volume of the periodical

42

Issue of the periodical within the volume

8

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

1289-1293

UT code for WoS article

000358165300006

EID of the result in the Scopus database

2-s2.0-84937979177