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Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059792" target="_blank" >RIV/00023001:_____/16:00059792 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/16:10322886 RIV/00064165:_____/16:10322886

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0009898116300055" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0009898116300055</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.cca.2016.01.005" target="_blank" >10.1016/j.cca.2016.01.005</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men

  • Original language description

    Aim: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in developed countries. This study aimed to confirm the effect of common putative CVD-associated gene variants (FTO rs17817449, KIF6 rs20455, 9p21 rs10757274 and 2q36.3 rs2943634) on CVD manifestation, and determine whether this effect differs between younger (<50 years) and older CVD patients. Methods: 1191 controls and 1889 MI patients were analyzed. All participants were Caucasian Czech males aged <65 years (532 were <50 years) who were examined at cardiology clinics in Prague, Czech Republic. Variants of FTO, 9p21, 2q36.3, and KIF-6 were genotyped using PCR-RFLP or TaqMan assay. Results: Variants of FTO (OR 1.48; 95% CI, 1.19-1.84 in a TT vs. GG comparison, p = 0.0005); 9p21 (OR 1.74; 95% CI, 1.41-2.14 in an AA vs. GG comparison, p = 0.0001); and 2836.3 (OR 134; 95%Cl, 1.09-1.65 in an AA vs. +C comparison, p = 0.006) were significantly associated with MI in the male Czech population. In contrast, genotype frequencies of KIF-6 (rs20455) were the same in patients and controls (P = 1.00). Nearly identical results were observed when a subset of young MI patients (N = 532, aged <50 years) was analyzed. Conclusion: We confirmed the importance of determining FTO, 9p21, and 2q36.3 variants as part of the genetic determination of MI risk in the Czech male population.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT12217" target="_blank" >NT12217: Genetic factors determining the risk of atherothrombotic vascular events in patients without classical risk factors of atherosclerosis and in patients treated with a statin.</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinica chimica acta

  • ISSN

    0009-8981

  • e-ISSN

  • Volume of the periodical

    454

  • Issue of the periodical within the volume

    February 15

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    5

  • Pages from-to

    119-123

  • UT code for WoS article

    000370305800022

  • EID of the result in the Scopus database