Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059792" target="_blank" >RIV/00023001:_____/16:00059792 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10322886 RIV/00064165:_____/16:10322886
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0009898116300055" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0009898116300055</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cca.2016.01.005" target="_blank" >10.1016/j.cca.2016.01.005</a>
Alternative languages
Result language
angličtina
Original language name
Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men
Original language description
Aim: Cardiovascular disease (CVD) is a major cause of morbidity and mortality in developed countries. This study aimed to confirm the effect of common putative CVD-associated gene variants (FTO rs17817449, KIF6 rs20455, 9p21 rs10757274 and 2q36.3 rs2943634) on CVD manifestation, and determine whether this effect differs between younger (<50 years) and older CVD patients. Methods: 1191 controls and 1889 MI patients were analyzed. All participants were Caucasian Czech males aged <65 years (532 were <50 years) who were examined at cardiology clinics in Prague, Czech Republic. Variants of FTO, 9p21, 2q36.3, and KIF-6 were genotyped using PCR-RFLP or TaqMan assay. Results: Variants of FTO (OR 1.48; 95% CI, 1.19-1.84 in a TT vs. GG comparison, p = 0.0005); 9p21 (OR 1.74; 95% CI, 1.41-2.14 in an AA vs. GG comparison, p = 0.0001); and 2836.3 (OR 134; 95%Cl, 1.09-1.65 in an AA vs. +C comparison, p = 0.006) were significantly associated with MI in the male Czech population. In contrast, genotype frequencies of KIF-6 (rs20455) were the same in patients and controls (P = 1.00). Nearly identical results were observed when a subset of young MI patients (N = 532, aged <50 years) was analyzed. Conclusion: We confirmed the importance of determining FTO, 9p21, and 2q36.3 variants as part of the genetic determination of MI risk in the Czech male population.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT12217" target="_blank" >NT12217: Genetic factors determining the risk of atherothrombotic vascular events in patients without classical risk factors of atherosclerosis and in patients treated with a statin.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinica chimica acta
ISSN
0009-8981
e-ISSN
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Volume of the periodical
454
Issue of the periodical within the volume
February 15
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
119-123
UT code for WoS article
000370305800022
EID of the result in the Scopus database
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