The FTO variant is associated with chronic complications of diabetes mellitus in Czech population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076528" target="_blank" >RIV/00023001:_____/18:00076528 - isvavai.cz</a>

Result on the web

<a href="https://ac.els-cdn.com/S0378111917310016/1-s2.0-S0378111917310016-main.pdf?_tid=b0883645-5ad5-4a2e-9306-39d458c9500b&acdnat=1523444127_fc2a6c7b01a8ffd158202f45697ca6b6" target="_blank" >https://ac.els-cdn.com/S0378111917310016/1-s2.0-S0378111917310016-main.pdf?_tid=b0883645-5ad5-4a2e-9306-39d458c9500b&acdnat=1523444127_fc2a6c7b01a8ffd158202f45697ca6b6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.gene.2017.11.040" target="_blank" >10.1016/j.gene.2017.11.040</a>

Result language

angličtina

Original language name

The FTO variant is associated with chronic complications of diabetes mellitus in Czech population

Original language description

Background: Genome-wide association studies have resulted in the identification of the FTO gene as an important genetic determinant of diabetes mellitus. The aim of this study was to confirm the role of this gene in the development of DM in the Czech-Slavonic population and to analyse whether this gene is associated with common DM complications. Methods: Two groups of patients (814 with T1DM and 848 with T2DM) and a group of healthy controls (2339 individuals) - both of Czech origin - were genotyped for the FTO rs17817449 SNP. ANOVA and logistic regression were used for the statistical evaluations. Results: The frequency of the GG genotype was significantly higher in T2DM (25.4% vs. 16.7%, P &lt; 0.0005) but not in T1DM patients (19.3% vs. 16.7%, P = 0.20) than in controls. The increased risk of development of diabetic nephropathy was observed both for T1DM patients (GG vs. TT homozygotes, P &lt; 0.01) and T2DM patients (G carriers vs. TT homozygotes, P &lt; 0.05). FTO genotype predicted the development of diabetic neuropathy (GG vs. TT comparison; P &lt; 0.01) in the T2DM patients only. No association between FTO genotype and development of retinopathy was detected. All presented values are after adjustment for age, sex, BMI and duration of diabetes. Conclusions: We confirm the association between the FTO rs17817449 SNP and susceptibility to T2DM in the Czech-Slavonic population. The same variant is associated with a spectrum of chronic complications in both types of diabetes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Gene

ISSN

0378-1119

e-ISSN

—

Volume of the periodical

642

Issue of the periodical within the volume

February 5

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

220-224

UT code for WoS article

000423892700028

EID of the result in the Scopus database

2-s2.0-85034257538