Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F20%3A43902458" target="_blank" >RIV/60076658:12110/20:43902458 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/20:00080248

Result on the web

<a href="https://doi.org/10.1002/mgg3.1361" target="_blank" >https://doi.org/10.1002/mgg3.1361</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mgg3.1361" target="_blank" >10.1002/mgg3.1361</a>

Result language

angličtina

Original language name

Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population

Original language description

The Czech governmental study suggests up to a 25% higher prevalence of type 2 diabetes mellitus (T2DM) in the Roma population than within the majority population. It is not known whether and to what extent these differences have a genetic background. Methods To analyze whether the frequencies of the alleles/genotypes of the FTO, TCF7L2, CDKN2A/2B, MAEA, TLE4, IGF2BP2, ARAP1, and KCNJ11 genes differ between the two major ethnic groups in the Czech Republic, we examined them in DNA samples from 302 Roma individuals and 298 Czech individuals. Results Compared to the majority population, Roma are more likely to carry risk alleles in the FTO (26% vs. 16% GG homozygotes, p &lt; .01), IGF2BP2 (22% vs. 10% TT homozygotes, p &lt; .0001), ARAP1 (98% vs. 95% of A allele carriers, p &lt; .005), and CDKN2A/2B (81% vs. 66% of TT homozygotes, p &lt; .001) genes; however, less frequently they are carriers of the TCF7L2 risk allele (34% vs. 48% of the T allele p &lt; .0005). Finally, we found significant accumulation of T2DM‐associated alleles between the Roma population in comparison with the majority population (25.4% vs. 15.2% of the carriers of at least 12 risk alleles; p &lt; .0001). Conclusion The increased prevalence of T2DM in the Roma population may have a background in different frequencies of the risk alleles of genes associated with T2DM development.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30302 - Epidemiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Genetics and Genomic Medicine

ISSN

2324-9269

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

"e1361"

UT code for WoS article

000542409400001

EID of the result in the Scopus database

2-s2.0-85087287430