Increased prevalence of the CVD-associated ANRIL allele in the Roma/Gypsy population in comparison with the majority Czech population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F21%3A43902468" target="_blank" >RIV/60076658:12110/21:43902468 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/21:00081142 RIV/00216208:11110/21:10428533

Result on the web

<a href="https://www.scielo.br/j/gmb/a/qSjzY4gDkT8Wt4Bjq3pdbsB/?format=pdf&lang=en" target="_blank" >https://www.scielo.br/j/gmb/a/qSjzY4gDkT8Wt4Bjq3pdbsB/?format=pdf&lang=en</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1590/1678-4685-GMB-2020-0405" target="_blank" >10.1590/1678-4685-GMB-2020-0405</a>

Result language

angličtina

Original language name

Increased prevalence of the CVD-associated ANRIL allele in the Roma/Gypsy population in comparison with the majority Czech population

Original language description

Cardiovascular disease (CVD) is a major cause of death around the world, with highest prevalence reported in minority Roma/Gypsy populations living in developed countries. Whether these differences are caused by unhealthy lifestyles or genetic factors remain unknown. The aim of our study was to examine the genotype frequencies of the rs10757274 polymorphism in the 9p.21 locus within ANRIL (antisense non-coding RNA in the INK4 locus), a long non-coding RNA located in the vicinity of the CDKN2A/2B inhibitors loci. ANRIL is understood to be the strongest genetic determinant of CVD in Caucasians. Using PCR-RFLP, we analysed the ANRIL rs10757274 polymorphism in 298 non-Roma (50% male) and 302 Roma/Gypsy (50% male) adult (39.5 ± 15.1 years and 39.2 ± 12.8 years, respectively) subjects. We found that frequencies of the ANRIL GG, GA and AA genotypes were 20.1%, 52.4% and 27.5% in the majority population and 32.9%, 47.9% and 19.2% in Roma/Gypsy subjects, respectively. The distribution of genotypes was deemed significantly different at P &lt; 0.001. Within the Roma/Gypsy population, we detected increased prevalence of the CVD-associated GG genotype. Increased prevalence of CVD among Roma/Gypsies subjects may be significantly linked to genetic background.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30307 - Nursing

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genetics and Molecular Biology

ISSN

1415-4757

e-ISSN

—

Volume of the periodical

44

Issue of the periodical within the volume

2

Country of publishing house

BR - BRAZIL

Number of pages

3

Pages from-to

"e20200405"

UT code for WoS article

000648531700001

EID of the result in the Scopus database

2-s2.0-85105991948