Possible gene-gender interaction between the SLCO1B1 polymorphism and statin treatment efficacy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F12%3A00058445" target="_blank" >RIV/00023001:_____/12:00058445 - isvavai.cz</a>
Result on the web
<a href="http://www.nel.edu/home.htm" target="_blank" >http://www.nel.edu/home.htm</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Possible gene-gender interaction between the SLCO1B1 polymorphism and statin treatment efficacy
Original language description
OBJECTIVES: A significant inter-individual variability in statin treatment efficacy is likely to have a strong genetic background. A candidate gene with the potential to influence statin treatment efficacy is SLCO1B1. This gene codes for the solute carrier organic anion transporter, which has been shown to regulate the hepatic uptake of statins and some other drugs. MATERIALS AND METHODS: The SLCO1B1 rs4149056 (T>C) polymorphism was successfully analysed in a group of 253 patients with dyslipidemia (treated with simvastin or atorvastatin, 10 or 20 mg per day) and 470 healthy normolipidemic controls. The polymorphism was analysed using nested PCR-RFLP. Lipid levels (total, LDL and HDL cholesterol; triglycerides) were analysed before and after 10-13 weeks of treatment. RESULTS: After treatment, as expected, there was a significant decrease both in the total cholesterol (7.60+-1.36 -> 5.37+-1.12 mmol/L, p<0.001) and LDL cholesterol (5.04+-1.34 -> 3.17+-0.99 mmol/L, p<0.001) levels. The di
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11307" target="_blank" >NT11307: Analysis of the genetic predisposition to the statin-induced side effects</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroendocrinology letters
ISSN
0172-780X
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
suppl. 2
Country of publishing house
SE - SWEDEN
Number of pages
4
Pages from-to
22-25
UT code for WoS article
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EID of the result in the Scopus database
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