B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00057600" target="_blank" >RIV/00023001:_____/13:00057600 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1097/TP.0b013e3182789a24" target="_blank" >http://dx.doi.org/10.1097/TP.0b013e3182789a24</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/TP.0b013e3182789a24" target="_blank" >10.1097/TP.0b013e3182789a24</a>

Result language
angličtina
Original language name
B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients
Original language description
Background: Molecular signatures have recently been identified in operationally tolerant long-term kidney transplant patients; however, their expression in patients on immunosuppression remains unclear. Methods. In this prospective study, the gene expression profiles of eight selected tolerance-associated genes (MS4A1, CD79B, TCL1A, TMEM176B, FOXP3, TOAG-1, MAN1A1, and TLR5) in the peripheral blood of 67 kidney transplant recipients at days 0, 7, 14, 21, 28, 60, 90, and at 6 and 12 months, and in graftbiopsies were measured. Similarly, using flow cytometry, CD45(+)CD19(+)CD3(-) B-cell counts were evaluated in the follow-up. Expression patterns were compared among patients with biopsy-proven acute rejection, borderline changes, and in rejection-free patients. A generalized linear mixed model with gamma distribution for repeated measures adjusted for induction therapy was used for statistical analysis of longitudinal data and Kruskal-Wallis test for case biopsy data. Results. Compared t
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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