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Conditional knockout of integrin alpha 2 beta 1 in murine megakaryocytes leads to reduced mean platelet volume

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00057955" target="_blank" >RIV/00023001:_____/13:00057955 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055094" target="_blank" >http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055094</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1371/journal.pone.0055094" target="_blank" >10.1371/journal.pone.0055094</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Conditional knockout of integrin alpha 2 beta 1 in murine megakaryocytes leads to reduced mean platelet volume

  • Original language description

    We have engineered a transgenic mouse on a C57BL/6 background that bears a floxed Itga2 gene. The crossing of this mouse strain to transgenic mice expressing Cre recombinase driven by the megakaryocyte (MK)-specific Pf4 promoter permits the conditional knockout of Itga2 in the MK/platelet lineage. Mice lacking MK alpha 2 beta 1 develop normally, are fertile, and like their systemic alpha 2 beta 1 knockout counterparts, exhibit defective adhesion to and aggregation induced by soluble type I collagen anda delayed onset to low dose fibrillar collagen-induced aggregation, results consistent with blockade or loss of platelet alpha 2 beta 1. At the same time, we observed a significant reduction in mean platelet volume, which is consistent with the reportedrole of alpha 2 beta 1 in MK maturation and proplatelet formation in vivo. This transgenic mouse strain bearing a floxed Itga2 gene will prove valuable to distinguish in vivo the temporal and spatial contributions of alpha 2 integrin in s

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FB - Endocrinology, diabetology, metabolism, nutrition

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PLoS ONE

  • ISSN

    1932-6203

  • e-ISSN

  • Volume of the periodical

    8

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    "e55094"

  • UT code for WoS article

    000314023600151

  • EID of the result in the Scopus database