Therapeutic DNA vaccination and RNA interference in inflammatory bowel disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058653" target="_blank" >RIV/00023001:_____/13:00058653 - isvavai.cz</a>

Result on the web

<a href="http://www.spandidos-publications.com/10.3892/ijmm.2013.1388" target="_blank" >http://www.spandidos-publications.com/10.3892/ijmm.2013.1388</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ijmm.2013.1388" target="_blank" >10.3892/ijmm.2013.1388</a>

Result language

angličtina

Original language name

Therapeutic DNA vaccination and RNA interference in inflammatory bowel disease

Original language description

Angiogenesis plays a significant role in numerous diseases. Recently, dysbalanced angiogenesis was found to be a component of pathogenesis of inflammatory bowel disease (IBD). Therefore, inhibition of angiogenesis is a novel therapeutic strategy that alleviates the inflammation and clinical outcomes of IBD. Bacteria act as vectors for the delivery of therapeutic sequences, a process that is particularly suitable in IBD, due to the natural occurrence of bacteria in gut. The main focus of the present study was the application of bacterial gene therapy in the modulation of angiogenesis in IBD. As a target molecule we used the main proangiogenic factor, vascular endothelial growth factor (VEGF). Bacterial strain Salmonella typhimurium SL7207 was used as agene delivery vector for oral application. DNA vaccination and RNA interference were examined and their efficiency in improving the course of the disease in dextran sulfate sodium-induced colitis in mice was compared. The two approaches y

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of molecular medicine

ISSN

1107-3756

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

2

Country of publishing house

GR - GREECE

Number of pages

5

Pages from-to

492-496

UT code for WoS article

000322370800029

EID of the result in the Scopus database

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