Molecular profiling of acute and chronic rejections of renal allografts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058703" target="_blank" >RIV/00023001:_____/13:00058703 - isvavai.cz</a>
Result on the web
<a href="http://www.hindawi.com/journals/cdi/2013/509259/" target="_blank" >http://www.hindawi.com/journals/cdi/2013/509259/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2013/509259" target="_blank" >10.1155/2013/509259</a>
Alternative languages
Result language
angličtina
Original language name
Molecular profiling of acute and chronic rejections of renal allografts
Original language description
Both antibody mediated (AMR) and T-cell mediated (TCMR) rejections either acute or chronic represent the main reason for late graft dysfunction. In this study we aimed to evaluate differences in the intrarenal expression patterns of immune system relatedgenes in acute and chronic rejections. Graft biopsies were performed and evaluated according to Banff classification. Using the TaqMan Low Density Array, the intrarenal expressions of 376 genes relating to immune response (B-cell activation, T-cell activation, chemokines, growth factors, immune regulators, and apoptosis) were analyzed in the four rejection categories: chronic AMR, chronic TCMR, acute AMR, and acute TCMR. The set of genes significantly upregulated in acute TCMR as compared to acute AMRwas identified, while no difference in gene expressions between chronic rejections groups was found. In comparison with functioning grafts, grafts that failed within the next 24 months after the chronic rejection morphological confirmatio
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical & Developmental Immunology
ISSN
1740-2522
e-ISSN
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Volume of the periodical
2013
Issue of the periodical within the volume
2013
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
"art. ID 509259"
UT code for WoS article
000327056200001
EID of the result in the Scopus database
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