Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure the ASTRONAUT randomized trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F13%3A00058800" target="_blank" >RIV/00023001:_____/13:00058800 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/13:N0000013

Result on the web

<a href="http://jama.jamanetwork.com/article.aspx?articleid=1666394" target="_blank" >http://jama.jamanetwork.com/article.aspx?articleid=1666394</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1001/jama.2013.1954" target="_blank" >10.1001/jama.2013.1954</a>

Result language

angličtina

Original language name

Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure the ASTRONAUT randomized trial

Original language description

IMPORTANCE:Hospitalizations for heart failure (HHF) represent a major health burden, with high rates of early postdischarge rehospitalization and mortality. OBJECTIVE: To investigate whether aliskiren, a direct renin inhibitor, when added to standard therapy, would reduce the rate of cardiovascular (CV) death or HF rehospitalization among HHF patients. INTERVENTION: All patients received 150 mg (increased to 300 mg as tolerated) of aliskiren or placebo daily, in addition to standard therapy. The study drug was continued after discharge for a median 11.3 months. MAIN OUTCOME MEASURES Cardiovascular death or HF rehospitalization at 6 months and 12 months. RESULTS: In total, 1639 patients were randomized, with 1615 patients included in the final efficacyanalysis cohort (808 aliskiren, 807 placebo). Mean age was 65 years; mean LVEF, 28%; 41% of patients had diabetes mellitus, mean estimated glomerular filtration rate, 67 mL/min/1.73 m2. At admission and randomization, median NT-proBNP lev

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JAMA

ISSN

0098-7484

e-ISSN

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Volume of the periodical

309

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1125-1135

UT code for WoS article

000316276500026

EID of the result in the Scopus database

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