Ivabradine in stable coronary artery disease without clinical heart failure.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33152278" target="_blank" >RIV/61989592:15110/14:33152278 - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/14:E0106093
Result on the web
<a href="http://www.nejm.org/doi/full/10.1056/NEJMoa1406430#t=articleTop" target="_blank" >http://www.nejm.org/doi/full/10.1056/NEJMoa1406430#t=articleTop</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1056/NEJMoa1406430" target="_blank" >10.1056/NEJMoa1406430</a>
Alternative languages
Result language
angličtina
Original language name
Ivabradine in stable coronary artery disease without clinical heart failure.
Original language description
An elevated heart rate is an established marker of cardiovascular risk. Previous analyses have suggested that ivabradine, a heart-rate-reducing agent, may improve outcomes in patients with stable coronary artery disease, left ventricular dysfunction, anda heart rate of 70 beats per minute or more. We conducted a randomized, double-blind, placebo-controlled trial of ivabradine, added to standard background therapy, in 19,102 patients who had both stable coronary artery disease without clinical heart failure and a heart rate of 70 beats per minute or more We randomly assigned patients to placebo or ivabradine, at a dose of up to 10 mg twice daily, with the dose adjusted to achieve a target heart rate of 55 to 60 beats per minute. The primary end point was a composite of death from cardiovascular causes or nonfatal myocardial infarction.At 3 months, the mean (+-SD) heart rate of the patients was 60.7+-9.0 beats per minute in the ivabradine group versus 70.6+-10.1 beats per minute in the
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
—
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
New England Journal of Medicine
ISSN
0028-4793
e-ISSN
—
Volume of the periodical
371
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1091-1099
UT code for WoS article
000341687300004
EID of the result in the Scopus database
—