Bradycardia and atrial fibrillation in patients with stable coronary artery disease treated with ivabradine: an analysis from the SIGNIFY study.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15120%2F15%3A33156706" target="_blank" >RIV/61989592:15120/15:33156706 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1093/eurheartj/ehv368" target="_blank" >http://dx.doi.org/10.1093/eurheartj/ehv368</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/eurheartj/ehv368" target="_blank" >10.1093/eurheartj/ehv368</a>

Result language

angličtina

Original language name

Bradycardia and atrial fibrillation in patients with stable coronary artery disease treated with ivabradine: an analysis from the SIGNIFY study.

Original language description

AIM: The aim of this study was to determine the impact of emergent bradycardia and atrial fibrillation (AF) on cardiovascular outcomes in 19 083 patients with stable coronary artery disease (CAD) receiving ivabradine or placebo (SIGNIFY, Study assessInGthe morbidity-mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease). METHODS AND RESULTS: Emergent bradycardia (resting heart rate <50 b.p.m. on 12-lead electrocardiogram) with ivabradine was reported in 3572 patients (37.4%) overall, and in 2242 (37.2%) patients with Canadian Cardiovascular Society (CCS) class GREATER-THAN OR EQUAL TO2 angina. There was no difference in outcomes over the course of the study in ivabradine-treated patients with and without emergent bradycardia in the whole population (2.5 vs. 2.9% per year, respectively, for primary composite endpoint of cardiovascular death or non-fatal myocardial infarction) or in the angina subgroup (2.5 vs. 3.2% per year). Neither was there an in

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Heart Journal (print)

ISSN

0195-668X

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

46

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

3291-3296

UT code for WoS article

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EID of the result in the Scopus database

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