Beta2-microglobulin as a diagnostic marker in cerebrospinal fluid: A Follow-Up Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059018" target="_blank" >RIV/00023001:_____/14:00059018 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/14:43908524 RIV/00064190:_____/14:#0000827
Result on the web
<a href="http://www.hindawi.com/journals/dm/2014/495402/" target="_blank" >http://www.hindawi.com/journals/dm/2014/495402/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/495402" target="_blank" >10.1155/2014/495402</a>
Alternative languages
Result language
angličtina
Original language name
Beta2-microglobulin as a diagnostic marker in cerebrospinal fluid: A Follow-Up Study
Original language description
Beta2-Microglobulin (beta 2-m) is a low molecular weight protein occurring in all body fluids. Its concentration increases in various pathologies. Increased values in cerebrospinal fluid (CSF) are ascribed to an activation of immune system. Using immunoturbidimetry, we examined concentrations of beta2-microglobulin in cerebrospinal fluid in a large group of 6274 patients with defined neurological diseases. Cell counts, total protein, albumin, glucose, lactic acid, immunoglobulins concentrations, and isofocusing (IEF) were also evaluated. We found substantial changes of CSF beta 2-m concentrations in purulent meningitis, leptomeningeal metastasis, viral meningitis/encephalitis, and neuroborreliosis, while in multiple sclerosis these changes were not significant. Intrathecal synthesis and immune activation were present in these clinical entities. A new normative study enables better understanding of beta2-microglobulin behavior in CSF.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Disease markers
ISSN
0278-0240
e-ISSN
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Volume of the periodical
2014
Issue of the periodical within the volume
may
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
495402
UT code for WoS article
000335971100001
EID of the result in the Scopus database
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