The relationship between estimated GFR based on the CKD-EPI formula and renal inulin clearance in potential kidney donors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059065" target="_blank" >RIV/00023001:_____/14:00059065 - isvavai.cz</a>
Result on the web
<a href="http://www.dustri.com/index.php?id=98&artId=12821" target="_blank" >http://www.dustri.com/index.php?id=98&artId=12821</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5414/CN108341" target="_blank" >10.5414/CN108341</a>

Result language
angličtina
Original language name
The relationship between estimated GFR based on the CKD-EPI formula and renal inulin clearance in potential kidney donors
Original language description
It is not yet clear whether or not renal function in the living donor can be sufficiently assessed by estimated glomerular filtration rate (GFR) using creatinine-based equations. The present paper investigates the relationship between GFR values determined using renal inulin clearance (Cin) and those estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Our study was performed in 287 potential kidney donors with a mean age of 48 +- 10 years. Mean Cin was 1.47 +- 0.28 (1.10 - 2.50) mL/s/1.73 m2. Total bias when using the CKDEPI formula was -0.0183 mL/s/1.73 m2, precision 0.263 mL/s/1.73 m2, and accuracy 90.6% within +- 30% of Cin. The sensitivity of CKD-EPI to estimate a decrease in Cin below 1.33 mL/s/1.73 m2 was 50.5%, with an 85% specificity of detecting a value above the cutoff. Receiver-operating curve analysis for the above produced an area under the curve of 0.766 +- 0.0285 (CI 0.712 - 0.813). For donor screening purposes, CKD-EPI should be inte
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Project
<a href="/en/project/NT13139" target="_blank" >NT13139: Early exercise training and selected nutrition after renal transplantation: endothelial progenitor cells and cardiovascular risk</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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