Lucifensins, the insect defensins of biomedical importance: The story behind maggot therapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059082" target="_blank" >RIV/00023001:_____/14:00059082 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/14:00435583

Result on the web

<a href="http://www.mdpi.com/1424-8247/7/3/251" target="_blank" >http://www.mdpi.com/1424-8247/7/3/251</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ph7030251" target="_blank" >10.3390/ph7030251</a>

Result language

angličtina

Original language name

Lucifensins, the insect defensins of biomedical importance: The story behind maggot therapy

Original language description

Defensins are the most widespread antimicrobial peptides characterised in insects. These cyclic peptides, 4-6 kDa in size, are folded into alfa-helical/beta-sheet mixed structures and have a common conserved motif of three intramolecular disulfide bridges with a Cys1-Cys4, Cys2-Cys5 and Cys3-Cys6 connectivity. They have the ability to kill especially Gram-positive bacteria and some fungi, but Gram-negative bacteria are more resistant against them. Among them are the medicinally important compounds lucifensin and lucifensin II, which have recently been identified in the medicinal larvae of the blowflies Lucilia sericata and Lucilia cuprina, respectively. These defensins contribute to wound healing during a procedure known as maggot debridement therapy (MDT) which is routinely used at hospitals worldwide. Here we discuss the decades-long story of the effort to isolate and characterise these two defensins from the bodies of medicinal larvae or from their secretions/excretions. Furthermore

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/GA203%2F08%2F0536" target="_blank" >GA203/08/0536: Antimicrobial peptides from insects for possible therapeutic applications</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmaceuticals [online]

ISSN

1424-8247

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

251-264

UT code for WoS article

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EID of the result in the Scopus database

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