Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F14%3A00059193" target="_blank" >RIV/00023001:_____/14:00059193 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/14:N0000015
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/ejhf.135/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/ejhf.135/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejhf.135" target="_blank" >10.1002/ejhf.135</a>
Alternative languages
Result language
angličtina
Original language name
Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES)
Original language description
AimsThe clinical outcomes for patients with worsening chronic heart failure (WCHF) remain exceedingly poor despite contemporary evidence-based therapies, and effective therapies are urgently needed. Accumulating evidence supports augmentation of cyclic guanosine monophosphate (cGMP) signalling as a potential therapeutic strategy for HF with reduced or preserved ejection fraction (HFrEF and HFpEF, respectively). Direct soluble guanylate cyclase (sGC) stimulators target reduced cGMP generation due to insufficient sGC stimulation and represent a promising method for cGMP enhancement. MethodsThe phase II SOluble guanylate Cyclase stimulatoR in heArT failurE Study (SOCRATES) programme consists of two randomized, parallel-group, placebo-controlled, double-blind, multicentre studies, SOCRATES-REDUCED (in patients with LVEF <45%) and SOCRATES-PRESERVED (in those with LVEF 45%), that will explore the pharmacodynamic effects, safety and tolerability, and pharmacokinetics of four dose regimens of
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European journal of heart failure
ISSN
1388-9842
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
1026-1038
UT code for WoS article
000341821900013
EID of the result in the Scopus database
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