Alterations in the basal ganglia in patients with brain tumours may be due to excessive iron deposition

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059100" target="_blank" >RIV/00023001:_____/15:00059100 - isvavai.cz</a>

Alternative codes found

RIV/00023884:_____/15:#0007172

Result on the web

<a href="http://www.spandidos-publications.com/10.3892/ol.2014.2638" target="_blank" >http://www.spandidos-publications.com/10.3892/ol.2014.2638</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ol.2014.2638" target="_blank" >10.3892/ol.2014.2638</a>

Result language

angličtina

Original language name

Alterations in the basal ganglia in patients with brain tumours may be due to excessive iron deposition

Original language description

The accumulation of iron in the brain is a common physiological process. However, alterations in the deposition of iron or other paramagnetic substances are associated with various diseases. In the present study, the deposition of paramagnetic substances in patients with brain tumours was evaluated using T-2 relaxometry. A total of 23 patients with untreated tumours or with recurrent tumours following treatment, together with a group of 19 age-matched healthy controls, were examined using T-2 relaxometry at 3T. The relaxation times in the basal ganglia, thalamus and white matter were evaluated. Significantly lower T-2 relaxation times were identified in the basal ganglia and thalamus of the patients with tumours, as compared with those of the controls (P<0.05). No statistically significant difference was identified between patients with untreated or recurrent brain tumours. The reduction in T-2 relaxation times in the brain tumour patients was possibly caused by the accumulation of iron, since iron homeostasis is known to be altered in patients with tumours. We propose that increased iron deposition is a consequence of a higher risk of oxidative stress caused by an increased iron concentration in the plasma or cerebrospinal fluid.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology letters

ISSN

1792-1074

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

1

Country of publishing house

GR - GREECE

Number of pages

4

Pages from-to

43-46

UT code for WoS article

000346638300007

EID of the result in the Scopus database

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