White matter changes in first episode psychosis and their relation to the size of sample studied: A DTI study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059254" target="_blank" >RIV/00023001:_____/15:00059254 - isvavai.cz</a>

Alternative codes found

RIV/67985807:_____/15:00441869 RIV/00023752:_____/15:43914680

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0920996415000596#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0920996415000596#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.schres.2015.01.029" target="_blank" >10.1016/j.schres.2015.01.029</a>

Result language

angličtina

Original language name

White matter changes in first episode psychosis and their relation to the size of sample studied: A DTI study

Original language description

Background: White matter abnormality has been recently proposed as a pathophysiological feature of schizophrenia (SZ). However, most of the data available has been gathered from chronic patients, and was therefore possibly confounded by factors such as duration of the disease, and treatment received. The extent and localization of these changes is also not clear. Methods: We examined a population of early stage SZ patients using diffusion tensor imaging (DTI). 77 SZ patients and 60 healthy controls (HCs) were included in the analysis using Tract-Based Spatial Statistics (TBSS). We have also analyzed 250 randomly created subsets of the original cohort, to investigate the relation between the result of TBSS analysis, and the size of the sample studied. Results: We have found a significant decrease in fractional anisotropy (FA) in the patient group. This change is present inmost major white matter (WM) tracts including the corpus callosum, superior and inferior longitudinal fasciculi, inferior fronto-occipital fasciculus, and posterior thalamic radiation. Furthermore, we identified a clear trend towards an increase in the number and spatial extent of significant voxels reported, with an increasing number of subjects included in the analysis. Conclusion: Our study shows that FA is significantly decreased in patients at an early stage of schizophrenia, and that the extent of this finding is dependent on the size of studied sample; therefore underpowered studies might produce results with false spatial localization.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

<a href="/en/project/GA13-23940S" target="_blank" >GA13-23940S: Personality and spontaneous brain activity during rest and movie watching: relation and structural determinants</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Schizophrenia research

ISSN

0920-9964

e-ISSN

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Volume of the periodical

162

Issue of the periodical within the volume

1-3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

22-28

UT code for WoS article

000349966400004

EID of the result in the Scopus database

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