White matter changes in first episode psychosis and their relationship to size of sample studied: A DTI study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909371" target="_blank" >RIV/00216208:11120/15:43909371 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.schres.2015.01.029" target="_blank" >http://dx.doi.org/10.1016/j.schres.2015.01.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.schres.2015.01.029" target="_blank" >10.1016/j.schres.2015.01.029</a>
Alternative languages
Result language
angličtina
Original language name
White matter changes in first episode psychosis and their relationship to size of sample studied: A DTI study
Original language description
Background: White matter abnormality has been recently proposed as a pathophysiological feature of schizophrenia (SZ). However, most of the data available has been gathered from chronic patients, and was therefore possibly confounded by factors such as duration of the disease, and treatment received. The extent and localization of these changes is also not clear. Methods: We examined a population of early stage SZ patients using diffusion tensor imaging (DTI). 77 SZ patients and 60 healthy controls (HCs) were included in the analysis using Tract-Based Spatial Statistics (TBSS). We have also analyzed 250 randomly created subsets of the original cohort, to investigate the relation between the result of TBSS analysis, and the size of the sample studied. Results: We have found a significant decrease in fractional anisotropy (FA) in the patient group. This change is present in most major white matter (WM) tracts including the corpus callosum, superior and inferior longitudinal fasciculi, in
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Schizophrenia Research
ISSN
0920-9964
e-ISSN
—
Volume of the periodical
162
Issue of the periodical within the volume
1-3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
22-28
UT code for WoS article
000349966400004
EID of the result in the Scopus database
—