Fatty Acid Signaling: The New Function of Intracellular Lipases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059256" target="_blank" >RIV/00023001:_____/15:00059256 - isvavai.cz</a>

Result on the web

<a href="http://www.mdpi.com/1422-0067/16/2/3831" target="_blank" >http://www.mdpi.com/1422-0067/16/2/3831</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms16023831" target="_blank" >10.3390/ijms16023831</a>

Result language

angličtina

Original language name

Fatty Acid Signaling: The New Function of Intracellular Lipases

Original language description

Until recently, intracellular triacylglycerols (TAG) stored in the form of cytoplasmic lipid droplets have been considered to be only passive "energy conserves". Nevertheless, degradation of TAG gives rise to a pleiotropic spectrum of bioactive intermediates, which may function as potent co-factors of transcription factors or enzymes and contribute to the regulation of numerous cellular processes. From this point of view, the process of lipolysis not only provides energy-rich equivalents but also acquires a new regulatory function. In this review, we will concentrate on the role that fatty acids liberated from intracellular TAG stores play as signaling molecules. The first part provides an overview of the transcription factors, which are regulated by fatty acids derived from intracellular stores. The second part is devoted to the role of fatty acid signaling in different organs/tissues. The specific contribution of free fatty acids released by particular lipases, hormone-sensitive lipase, adipose triacylglycerol lipase and lysosomal lipase will also be discussed.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of molecular sciences

ISSN

1422-0067

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

25

Pages from-to

3831-3855

UT code for WoS article

000350333600094

EID of the result in the Scopus database

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