In vivo monitoring of rat macrophages labeled with poly(L-lysine)-iron oxide nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059491" target="_blank" >RIV/00023001:_____/15:00059491 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/15:00446014 RIV/61389013:_____/15:00446014
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33292/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.33292/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbm.b.33292" target="_blank" >10.1002/jbm.b.33292</a>
Alternative languages
Result language
angličtina
Original language name
In vivo monitoring of rat macrophages labeled with poly(L-lysine)-iron oxide nanoparticles
Original language description
Coprecipitation of FeCl2 and FeCl3 with aqueous ammonia was used to prepare iron oxide nanoparticles dispersible in aqueous medium. Oxidation of the particles with sodium hypochlorite then yielded maghemite (g-Fe2O3) nanoparticles which were coated with two types of coating -D-mannose or poly(L-lysine) (PLL) as confirmed by FTIR analysis. The particles were <10 nm according to transmission electron microscopy. Their hydrodynamic particle size was 180 nm (by dynamic light scattering). The D-mannose-, PLL-coated, and neat g-Fe2O3 particles as well as commercial ResovistVR were used to label rat macrophages. The viability and contrast properties of labeled macrophages were compared. PLL-coated g-Fe2O3 nanoparticles were found optimal. The labeled macrophages were injected to rats monitored in vivo by magnetic resonance imaging up to 48 h. Transport of macrophages labeled with PLL-g-Fe2O3 nanoparticles in rats was confirmed. Tracking of macrophages using the developed particles can be used formonitoring of inflammations and cell migration in cell therapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN
1552-4973
e-ISSN
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Volume of the periodical
103
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1141-1148
UT code for WoS article
000358484700001
EID of the result in the Scopus database
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