Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriacylglycerolemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059497" target="_blank" >RIV/00023001:_____/15:00059497 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0899900715001586" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0899900715001586</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nut.2015.03.011" target="_blank" >10.1016/j.nut.2015.03.011</a>

Result language

angličtina

Original language name

Conjugated linoleic acid reduces visceral and ectopic lipid accumulation and insulin resistance in chronic severe hypertriacylglycerolemia

Original language description

Objective: The metabolic health effects of conjugated linoleic acid (CIA), which is one of the principal polyunsaturated fatty acids, are controversial and still not fully accepted. The aim of this study was to examine the effects of CIA on adiposity, ectopic lipid accumulation, and insulin-resistant states in a metabolic syndrome model of non-obese hereditary rats with hypertriacylglycerolmia (HHTg). Methods: Groups of adult male HHTg rats were fed a high-carbohydrate diet (70% sucrose) with a 2% mixture of CIA isomers, or with the same amount of sunflower oil (control group) for 2 mo. Results: CIA supplementation decreased body weight gain (P < 0.05) and visceral adipose tissue weight (P < 0.01), and distinctively reduced serum triacylglycerols (P < 0.01) and triacylglycerol accumulation in the liver, heart, muscle, and aorta. CIA-treated rats exhibited increased insulin sensitivity in the adipose (P < 0.01), a higher release of fatty acids (P < 0.001), and increased adiponectin secretion (P < 0.01),In the skeletal muscle, CIA supplementation was associated with increased glucose oxidation (P < 0.01) and an elevated anti-inflammatory index (P < 0.05), according to phospholipid fatty acid composition. In the liver, CIA reduced the oxidized form of glutathione and elevated the activity of glutathione-dependent antioxidant enzymes. Conclusion: Results suggest that CIA supplementation may protect against HHTg-induced dyslipidemia, ectopic lipid deposition, and insulin resistance. Increased glucose oxidation in the skeletal muscle as well as adiponectin secretion may play a role in the mechanism of the CIA action. Results suggest that CIA could reduce the negative consequences of HHTg and metabolic syndrome.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrition

ISSN

0899-9007

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

7-8

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

1045-1051

UT code for WoS article

000356998000023

EID of the result in the Scopus database

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