Beneficial effects of troxerutin on metabolic disorders in non-obese model of metabolic syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73600909" target="_blank" >RIV/61989592:15110/19:73600909 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/19:00078373

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690532/pdf/pone.0220377.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690532/pdf/pone.0220377.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0220377" target="_blank" >10.1371/journal.pone.0220377</a>

Result language

angličtina

Original language name

Beneficial effects of troxerutin on metabolic disorders in non-obese model of metabolic syndrome

Original language description

Troxerutin (TRX) has a beneficial effect on blood viscosity and platelet aggregation, and is currently used for the treatment of chronic varicosity. Recently, TRX can improve lipid abnormalities, glucose intolerance and oxidative stress in high-fat diet-induced metabolic disorders. In this study, we tested the effect of TRX on metabolic syndrome-associated disorders using a non-obese model of metabolic syndrome–the Hereditary Hypertriglyceridaemic rats (HHTg). Adult male HHTg rats were fed standard diet without or with TRX (150 mg/kg bwt/day for 4 weeks). Compared to untreated rats, TRX supplementation in HHTg rats decreased serum glucose (p&lt;0.05) and insulin (p&lt;0.05). Although blood lipids were not affected, TRX decreased hepatic cholesterol concentrations (p&lt;0.01) and reduced gene expression of HMGCR, SREBP2 and SCD1 (p&lt;0.01), involved in cholesterol synthesis and lipid homeostasis. TRXtreated rats exhibited decreased lipoperoxidation and increased activity of antioxidant enzymes SOD and GPx (p&lt;0.05) in the liver. In addition, TRX supplementation increased insulin sensitivity in muscles and epididymal adipose tissue (p&lt;0.05). Elevated serum adiponectin (p&lt;0.05) and decreased muscle triglyceride (p&lt;0.05) helped improve insulin sensitivity. Among the beneficial effects of TRX were changes to cytochrome P450 family enzymes. Hepatic gene expression of CYP4A1, CYP4A3 and CYP5A1 (p&lt;0.01) decreased, while there was a marked elevation in gene expression of CYP1A1 (p&lt;0.01).

Czech name

—

Czech description

—

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/GA17-08888S" target="_blank" >GA17-08888S: Effect of silymarin combined with hypolipidemics on mechanisms leading to lipids accumulation, oxidative stress and inflammation in metabolic syndrome</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

—

Volume of the periodical

14

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

1-12

UT code for WoS article

000485006800012

EID of the result in the Scopus database

2-s2.0-85070703834