All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Impact of inherited prothrombotic disorders on the long-term clinical outcome of percutaneous transluminal angioplasty in patients with diabetes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059539" target="_blank" >RIV/00023001:_____/15:00059539 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.hindawi.com/journals/jdr/2015/369758/" target="_blank" >http://www.hindawi.com/journals/jdr/2015/369758/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2015/369758" target="_blank" >10.1155/2015/369758</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Impact of inherited prothrombotic disorders on the long-term clinical outcome of percutaneous transluminal angioplasty in patients with diabetes

  • Original language description

    The aim of our study was to analyse inherited thrombotic disorders that influence the long-term outcome of PTA. Methods. Diabetic patients with peripheral arterial disease (PAD) treated by PTA in our centre between 2008 and 2011 were included in the study. Patients were divided into unsuccessful PTA group (75 patients), successful PTA group (58 patients), and control group (65 patients, with diabetes but no PAD). Diagnosis of inherited thrombotic disorders included mutation in factor V (Leiden), factor II (prothrombin), and mutation in genes for methylenetetrahydrofolate reductase-MTHFR (C677T and A1298C). Results. The genotypic frequency of Leiden allele G1691A was significantly associated with a risk of unsuccessful PTA in comparison with successful PTA group and control group (OR 8.8 (1.1-70.6), p = 0.041, and OR 9.8 (1.2-79.2), p = 0.032, resp.). However, we only observed a trend for the association of the prothrombin allele G20210A and risk of PTA failure. The frequencies of alleles of MTHFR 677 or 1298 did not differ significantly among the groups. Conclusion. Our study showed higher frequency of heterozygous form of Leiden mutation in diabetic patients with unsuccessful outcome of PTA in comparison with patients with successful PTA and diabetic patients without PAD.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FB - Endocrinology, diabetology, metabolism, nutrition

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of diabetes research [online]

  • ISSN

    2314-6745

  • e-ISSN

  • Volume of the periodical

    2015

  • Issue of the periodical within the volume

    June 29

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    5

  • Pages from-to

    "art ID 369758"

  • UT code for WoS article

    000358525400001

  • EID of the result in the Scopus database