Polymorphism G - 308A in the Promoter of the Tumor Necrosis Factor-alfa gene and Its Association with the Risk of Venous Thromboembolism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871394" target="_blank" >RIV/62157124:16370/12:43871394 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1097/MBC.0b013e3283527506" target="_blank" >http://dx.doi.org/10.1097/MBC.0b013e3283527506</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MBC.0b013e3283527506" target="_blank" >10.1097/MBC.0b013e3283527506</a>

Result language

angličtina

Original language name

Polymorphism G - 308A in the Promoter of the Tumor Necrosis Factor-alfa gene and Its Association with the Risk of Venous Thromboembolism

Original language description

The main abnormalities associated with the increased risk of venous thrombosis (VT) are the inherited deficiencies of antithrombin, protein C, protein S, the point mutations known as factor V Leiden (FVL) and factor II (FII) G20210A. The association of other specific genes with thrombotic risk is less known. G-308A polymorphism in the promoter area of the gene coding for tumor necrosis factor alpha (TNF-alfa) is associated with an increased transcription activity of this gene, increased TNF-alfa production and subsequent predisposition to some illnesses. The aim of this work was to study the link between this polymorphism and predisposition to deep venous thrombosis. The research determined the frequency of the variant allele -308A in the gene for TNF-alfa in a group of 67 patients diagnosed with deep venous thrombosis and in a group of 62 healthy volunteers. We confirmed statistically significant link between the occurrence of the variant allele -308A and deep venous thrombosis (P = 0

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood coagulation & fibrinolysis

ISSN

0957-5235

e-ISSN

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Volume of the periodical

23

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

316-319

UT code for WoS article

000303655600012

EID of the result in the Scopus database

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