Three polymorphisms in promoter of protein c gene with endothelial protein c receptor gene and risk of venous thrombosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43871808" target="_blank" >RIV/62157124:16370/13:43871808 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1097/MBC.0b013e32836466cb" target="_blank" >http://dx.doi.org/10.1097/MBC.0b013e32836466cb</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MBC.0b013e32836466cb" target="_blank" >10.1097/MBC.0b013e32836466cb</a>

Result language

angličtina

Original language name

Three polymorphisms in promoter of protein c gene with endothelial protein c receptor gene and risk of venous thrombosis

Original language description

The primary abnormalities that are associated with a risk of venous thrombosis are the deficiencies of protein C. Protein C (PROC), encoded by the PROC gene, acts through its affinity for binding to its transmembrane endothelial cell protein C receptor (EPCR) encoded by the EPCR gene. The objective of the study was to analyze the link between three polymorphisms in the promoter of PROC gene, the polymorphism in the EPCR gene and the occurrence of venous thrombosis. We genotyped 135 individuals - 51 cases with documented venous thrombosis and 84 healthy volunteers without a history of venous thrombosis. The occurrence of the TAA haplotype of PROC gene was significantly more frequent in the controls (N=48; 57.1%), compared with the patients (N=18; 35.3%), (P=0.0206). The healthy individuals were also significantly often carriers of the TAA haplotype and the standard genotype AA of EPCR gene (50 vs. 25.5%) than the patients (P=0.0066). The frequency of haplotypes CAA and CGT of PROC gene

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood coagulation & fibrinolysis

ISSN

0957-5235

e-ISSN

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Volume of the periodical

24

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

814-817

UT code for WoS article

000326815600004

EID of the result in the Scopus database

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