Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9362" target="_blank" >RIV/00216208:11110/11:9362 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/11:9362

Result on the web

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2011.09.015" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2011.09.015</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Association of pregnancy-associated plasma protein A polymorphism with preeclampsia - A pilot study

Original language description

The aim of the study was to investigate genetic and biochemical background of PAPP-A (pregnancy-associated plasma protein A) in patients with risk pregnancies. Five PAPP-A gene polymorphisms and PAPP-A maternal serum levels were studied in together 165 women in third trimester pregnancies complicated with threatening preterm labour (n=98), preeclampsia (n=35), intrauterine growth restriction (n=34) and ICP (intrahepatic cholestasis of pregnancy) (n=15). 114 healthy pregnant women served as controls. Preeclamptic patients had significantly higher frequency of TT genotype of Cys327Cys polymorphism compared to controls (p<0.01). Patients with ICP had increased serum levels of PAPP-A compared to controls and correlation analysis showed significant relationship between PAPP-A and CRP (C-reactive protein) in the patients with intrauterine growth restriction (r=0.49, p= 0.007).Our study indicates the association of TT genotype of Cys327Cys polymorphism of the PAPP-A gene with preeclampsia. Ho

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Volume of the periodical

44

Issue of the periodical within the volume

17

Country of publishing house

CA - CANADA

Number of pages

5

Pages from-to

1380-1384

UT code for WoS article

000297570300004

EID of the result in the Scopus database

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