Receptor for advanced glycation end products (RAGE) and glyoxalase I gene polymorphisms in pathological pregnancy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12624" target="_blank" >RIV/00216208:11110/12:12624 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22340/12:43893426 RIV/00064165:_____/12:12624

Result on the web

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2012.06.031" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2012.06.031</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Receptor for advanced glycation end products (RAGE) and glyoxalase I gene polymorphisms in pathological pregnancy

Original language description

Objectives: The aim of the study was to analyze polymorphisms of receptor for advanced glycation end products (RAGE) gene, and glyoxalase I gene and soluble RAGE, sRAGE, in physiological and pathological pregnancy. Design and methods: Polymorphisms of RAGE gene (-429 T/C, -374 T/A, 557 G/A, 2184 A/G) and glyoxalase I gene (A419C) and sRAGE serum levels were determined in 284 women with pathological and physiological pregnancy. Results: No differences in distribution of genotype and allelic frequencies of studied polymorphisms were found. GA genotype of RAGE 557 G/A polymorphism (known as Gly82Ser) is associated with lower sRAGE serum levels in healthy pregnant women compared to GG genotype (483 +/- 104 vs. 692 262 +/- pg/mL, p = 0.008). sRAGE correlates negatively with ALT in patients with pregnancy intrahepatic cholestasis (r = -0.536, p = 0.05). Conclusions: We did not show any association of RAGE and glyoxalase I gene polymorphisms with pathological pregnancy, however further studie

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Volume of the periodical

45

Issue of the periodical within the volume

16-17

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

1409-1414

UT code for WoS article

000311064200025

EID of the result in the Scopus database

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