Pregnancy-Associated Plasma Protein A (PAPP-A) and Preeclampsia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10287234" target="_blank" >RIV/00216208:11110/14:10287234 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/14:10287234

Result on the web

<a href="http://dx.doi.org/10.1016/B978-0-12-800094-6.00005-4" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-800094-6.00005-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-800094-6.00005-4" target="_blank" >10.1016/B978-0-12-800094-6.00005-4</a>

Result language

angličtina

Original language name

Pregnancy-Associated Plasma Protein A (PAPP-A) and Preeclampsia

Original language description

Pregnancy-associated plasma protein A (PAPP-A) is a key regulator of insulin-like growth factor bioavailability essential for normal fetal development. In maternal blood, this protein increases with gestational age and then rapidly decreases after delivery. It is routinely used for Down syndrome screening in the first trimester of pregnancy, and its decrease compared to a normal pregnancy indicates an increased risk for both chromosomal anomalies and adverse pregnancy outcomes. It belongs to a group ofbiomarkers that predict later preeclampsia development, primarily early onset preeclampsia; however, it should be combined with a Doppler ultrasonography of the uterine artery (pulsatile index) and other biochemical and maternal factors to achieve a higher detection rate with an acceptable false positivity rate. Some studies have demonstrated an even more pronounced decrease of PAPP-A in the early second trimester of pregnancy in women who subsequently develop preeclampsia compared with

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advances in Clinical Chemistry

ISSN

0065-2423

e-ISSN

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Volume of the periodical

63

Issue of the periodical within the volume

-

Country of publishing house

US - UNITED STATES

Number of pages

41

Pages from-to

169-209

UT code for WoS article

000331015900005

EID of the result in the Scopus database

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