Significantly higher incidence of skin cancer than other malignancies in patients after heart transplantation. A retrospective cohort study in the Czech Republic
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F15%3A00059685" target="_blank" >RIV/00023001:_____/15:00059685 - isvavai.cz</a>
Alternative codes found
RIV/00064211:_____/15:#0000461 RIV/00216208:11130/15:10315834
Result on the web
<a href="http://biomed.papers.upol.cz/artkey/bio-201504-0021_significantly_higher_incidence_of_skin_cancer_than_other_malignancies_in_patients_after_heart_transplantation.php" target="_blank" >http://biomed.papers.upol.cz/artkey/bio-201504-0021_significantly_higher_incidence_of_skin_cancer_than_other_malignancies_in_patients_after_heart_transplantation.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2015.011" target="_blank" >10.5507/bp.2015.011</a>
Alternative languages
Result language
angličtina
Original language name
Significantly higher incidence of skin cancer than other malignancies in patients after heart transplantation. A retrospective cohort study in the Czech Republic
Original language description
Aims. To perform the first study in Czech Republic on heart transplant recipients (HTRs), compare the risks for different types of cancer and provide comprehensive analysis of skin cancer and other types of cancer morbidity from which we would be able to derive an evidence-based skin cancer surveillance program. Materials and Methods. A retrospective cohort study was performed to determine and compare standardized morbidity ratio (SMR) of different types of cancer developed after heart transplantation. We analysed data obtained from medical documentation of 603 HTRs transplanted between 1993 and 2010. Results. 191 incident cases of malignancy occurred in 123 HTRs (20.4%). According to expectations, nonmelanoma skin cancer was the most frequent type of malignancy (119 cases) with SMR 7.6 (P < 0.001), followed by lung cancer with SMR 2.7 (P < 0.001). SMR for melanoma was 2.5, P = 0.129. Other types of cancer in HTRs (prostate and kidney cancer) were less frequent (SMR 2.06, P = 0.038 and SMR 2.03, P = 0.122). Conclusion. The risk of malignancy development is significantly higher for HTRs compared to the general population. Squamous cell carcinoma of the skin is the most frequent type of cancer followed by basal cell carcinoma. These findings emphasise the importance of regular skin cancer screening in HTRs.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14203" target="_blank" >NT14203: The incidence of neoplasms in patients after heart transplantation - identification of significant factors for use in secondary prevention.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
159
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
648-651
UT code for WoS article
000366566700021
EID of the result in the Scopus database
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