Immunosuppressive therapy in the posttransplant period and skin cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060145" target="_blank" >RIV/00023001:_____/16:00060145 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/16:10332812 RIV/00064211:_____/16:N0000022

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/dth.12379/epdf?r3_referer=wol&tracking_action=preview_click&show_checkout=1&purchase_referrer=onlinelibrary.wiley.com&purchase_site_license=PUBLICATION_OUTSIDE_OF_LICENSE_PERIOD" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/dth.12379/epdf?r3_referer=wol&tracking_action=preview_click&show_checkout=1&purchase_referrer=onlinelibrary.wiley.com&purchase_site_license=PUBLICATION_OUTSIDE_OF_LICENSE_PERIOD</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/dth.12379" target="_blank" >10.1111/dth.12379</a>

Result language

angličtina

Original language name

Immunosuppressive therapy in the posttransplant period and skin cancer

Original language description

AIMS: To determine the incidence of malignancies in renal transplant recipients (RTRs) and to analyze the association between the risk of skin cancer and immunosuppressive regiments used in the posttransplant period. MATERIALS AND METHODS: A cohort study was performed on 797 RTRs. Standardized morbidity ratio (SMR) was calculated for the most common types of cancer developed in the posttransplant period and different types of immunosuppressive therapy used in the cohort. RESULTS: 192 cases of malignancies were diagnosed in 86 RTRs (10.8%). Nonmelanoma skin cancer (NMSC) was the most frequent type of cancer (SMR = 6.42, p = 0.000), followed by renal cancer (SMR = 5.9, p = 0.000), malignant melanoma (SMR = 2.59, p = 0.080), and prostate cancer (SMR = 1.21, p = 0.593). The risk to develop NMSC was significantly higher in the group where cyclosporine has been used besides tacrolimus, mycophenolatemophetil and steroids as well as in the group treated with the combination without cyclosporine (SMR = 9.62, p = 0.001 and SMR = 5.18, p = 0.000). Furthermore, the risk was significantly higher in RTRs receiving anti-thymocyte globulin within induction therapy (SMR = 4.14, p = 0.000). CONCLUSION: The preliminary results indicate that the risk of NMSC in RTRs is significantly higher than in the general population and thus emphasize the need to improve preventive strategies in the Czech transplant population.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Dermatologic therapy

ISSN

1396-0296

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

433-436

UT code for WoS article

000390561300012

EID of the result in the Scopus database

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