All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Conditional knockout of collecting duct bradykinin B2 receptors exacerbates angiotensin II-induced hypertension during high salt intake

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059588" target="_blank" >RIV/00023001:_____/16:00059588 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/16:10323754

  • Result on the web

    <a href="http://www.tandfonline.com/doi/abs/10.3109/10641963.2015.1047945?journalCode=iceh20" target="_blank" >http://www.tandfonline.com/doi/abs/10.3109/10641963.2015.1047945?journalCode=iceh20</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3109/10641963.2015.1047945" target="_blank" >10.3109/10641963.2015.1047945</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Conditional knockout of collecting duct bradykinin B2 receptors exacerbates angiotensin II-induced hypertension during high salt intake

  • Original language description

    We elucidated the role of collecting duct kinin B2 receptor (B2R) in the development of salt-sensitivity and angiotensin II (ANG II)-induced hypertension. To this end, we used a Cre-Lox recombination strategy to generate mice lacking Bdkrb2 gene for B2R in the collecting duct (Hoxb7-Cretg/+:Bdkrb2flox/flox). In 3 groups of control (Bdkrb2flox/flox) and 3 groups of UBBdkrb2-/- mice, systolic blood pressure (SBP) responses to high salt intake (4 or 8% NaCl; HS) were monitored by radiotelemetry in comparison with standard salt diet (0.4% NaCl) prior to and during subcutaneous ANG II infusion (1000 ng/min/kg) via osmotic minipumps. High salt intakes alone for 2 weeks did not alter SBP in either strain. ANG II significantly increased SBP equally in control (121 +- 2 to 156 +- 3 mmHg) and UBBdkrb2-/- mice (120 +- 2 to 153 +- 2 mmHg). The development of ANG II-induced hypertension was exacerbated by 4%HS in both control (125 +- 3 to 164 +- 5 mmHg) and UBBdkrb2-/- mice (124 +- 2 to 162 +- 3 mmHg) during 2 weeks. Interestingly, 8%HS caused a more profound and earlier ANG II-induced hypertension in UBBdkrb2-/- (129 +- 2 to 166 +- 3 mmHg) as compared to control (128 +- 2 to 158 +- 2 mmHg) and it was accompanied by body weight loss and increased mortality. In conclusion, targeted inactivation of B2R in the renal collecting duct does not cause salt-sensitivity; however, collecting duct B2R attenuates the hypertensive actions of ANG II under conditions of very high salt intake.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NT14011" target="_blank" >NT14011: The impact of bradykinin B2 receptor gene inactivation in mouse distal tubule on sodium handling in experimental models of hypertension</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical and experimental hypertension

  • ISSN

    1064-1963

  • e-ISSN

  • Volume of the periodical

    38

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    1-9

  • UT code for WoS article

    000367921300001

  • EID of the result in the Scopus database