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Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00089334" target="_blank" >RIV/00216224:14110/16:00089334 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1038/hr.2015.132" target="_blank" >http://dx.doi.org/10.1038/hr.2015.132</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/hr.2015.132" target="_blank" >10.1038/hr.2015.132</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Impaired response of regulator of G alpha q signaling-2 mRNA to angiotensin II and hypertensive renal injury in Dahl salt-sensitive rats

  • Original language description

    Dahl salt-sensitive (Dahl S) rats are prone to salt-dependent hypertension with severe organ damage, including stroke, cardiac failure and renal insufficiency. The mechanism for this susceptibility to kidney injury has not been elucidated. The present study proposed that an upregulation of intracellular signaling of angiotensin II (Ang-II) is responsible for the susceptibility to hypertensive kidney injury in Dahl S rats. Spontaneously hypertensive rats exhibited higher systolic blood pressure (SBP) and lower kidney damage than Dahl S rats fed a high-salt diet for 2 weeks. Ang-II infusion for 4 weeks significantly increased SBP in Dahl S and Dahl salt-resistant (Dahl R) rats fed a low-salt diet. The increase in SBP in Dahl S rats was associated with significant kidney injury with greater glomerular sclerosis (Po0.001). The expression of regulatory protein of Gaq signaling-2 (RGS2) mRNA in the aortic walls in response to Ang-II infusion was lower in Dahl S than Dahl R rats (Po0.05).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FP - Other medical fields

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Hypertension Research

  • ISSN

    0916-9636

  • e-ISSN

  • Volume of the periodical

    39

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    210-216

  • UT code for WoS article

    000373847300007

  • EID of the result in the Scopus database