The role of epicardial adipose tissue in heart disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059709" target="_blank" >RIV/00023001:_____/16:00059709 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/16:N0000034 RIV/00216208:11110/16:10324835 RIV/00064165:_____/16:10324835
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/65/65_23.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/65/65_23.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The role of epicardial adipose tissue in heart disease
Original language description
Recent studies focused on epicardial fat, formerly relatively neglected component of the heart, have elucidated some of its key roles. It possesses several properties that can distinguish it from other adipose tissue depots. Its unique anatomical location in the heart predisposes the epicardial fat to be an important player in the physiological and biochemical regulation of cardiac homeostasis. Obesity is associated with an increase in epicardial fat mass. Excess of cardiac fat can contribute to greater left ventricular mass and work, diastolic dysfunction and attenuated septal wall thickening. Imbalance in adipokines levels secreted in autocrine or paracrine fashion by epicardial fat can contribute to the activation of the key atherogenic pathways in the setting of metabolic syndrome. Epicardial fat has also been identified as an important source of pro-inflammatory mediators worsening endothelial dysfunction, eventually leading to coronary artery disease. Increased production of pro-inflammatory factors by epicardial fat can also contribute to systemic insulin resistance in patients undergoing cardiac surgery. Here we review the most important roles of epicardial fat with respect to heart disease in the context of other underlying pathologies such as obesity and type 2 diabetes mellitus.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NV15-26854A" target="_blank" >NV15-26854A: The role of epicardial adipose tissue in heart disease: novel mechanisms of action and its therapeutic modulation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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