The role of inflammation in epicardial adipose tissue in heart diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076897" target="_blank" >RIV/00023001:_____/18:00076897 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/18:N0000019 RIV/00216208:11110/18:10375112 RIV/00064165:_____/18:10375112
Result on the web
<a href="http://europepmc.org/abstract/med/29318960" target="_blank" >http://europepmc.org/abstract/med/29318960</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1381612824666180110102125" target="_blank" >10.2174/1381612824666180110102125</a>
Alternative languages
Result language
angličtina
Original language name
The role of inflammation in epicardial adipose tissue in heart diseases
Original language description
Epicardial adipose tissue is not only a specific adipose tissue depot but also an active endocrine organ producing numerous substances with an important role in the development of obesity-related heart diseases. It is located between myocardium and visceral pericardium and consists predominantly of adipocytes, immunocompetent cells, ganglia and interconnecting nerve branches. Several studies documented a positive correlation between pericardial and epicardial fat and left ventricular hypertrophy and septal thickening, leading to diastolic dysfunction, electrocardiographic abnormalities and facilitating cardiac failure. The cellular cross-talks between epicardial fat and myocardium may include both the vasocrine and the paracrine mechanisms. Adipokines secreted from epicardial adipose tissue, vascular and stromal cells diffuse into interstitial fluid crossing the adventitia, media and intima and modulate cardiac function and cardiomyocyte phenotype and survival. In this article, we review the significance of epicardial adipose tissue and its association with cardiovascular diseases, cellular interactions between epicardial fat and myocardium, secretions of adipokines and inflammatory mediators and a potential of epicardial fat as a therapeutic target for the prevention of obesity-related heart diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV15-26854A" target="_blank" >NV15-26854A: The role of epicardial adipose tissue in heart disease: novel mechanisms of action and its therapeutic modulation</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current pharmaceutical design
ISSN
1381-6128
e-ISSN
—
Volume of the periodical
24
Issue of the periodical within the volume
3
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
13
Pages from-to
297-309
UT code for WoS article
000430247000005
EID of the result in the Scopus database
2-s2.0-85047828533