Genetic variants within telomere-associated genes, leukocyte telomere length and the risk of acute coronary syndrome in Czech women
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059823" target="_blank" >RIV/00023001:_____/16:00059823 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S000989811530111X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S000989811530111X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cca.2015.12.041" target="_blank" >10.1016/j.cca.2015.12.041</a>
Alternative languages
Result language
angličtina
Original language name
Genetic variants within telomere-associated genes, leukocyte telomere length and the risk of acute coronary syndrome in Czech women
Original language description
The association between leukocyte telomere length (LTL) and cardiovascular disease (CVD) has been published in many reports, although almost exclusively in men. In our study we analysed the association between LTL and five selected variants within three candidate genes (TERC rs12696304; TERF2IP rs3784929 and rs8053257; UCP2 rs659366 and rs622064), which are not only involved in telomere-length maintenance but also potentially associated with higher risk of acute coronary syndrome (ACS) in Czech women (505 cases and 642 controls). We detected significantly shorter LTL in women with ACS (P < 0.001), but the difference disappeared after multiple adjustments. We did not find any significant associations between analysed variants and LTL, except for rs622064 within the UCP2 gene, in which case AA homozygotes had a higher LTL (P < 0.04). Genotype frequencies of the analysed SNP5 did not differ between controls and women with ACS. Variants within UCP2 (rs622064; CC vs. A allele carriers OR = 1.61; 95% CI: 121-2.15, P < 0.002) and within TERF2IP (rs8053257; A allele carriers vs. GG, OR = 1.78; 95% CI: 1.07-3.18, P < 0.03) were associated with increased risk of type 2 diabetes mellitus (T2DM). Analysed polymorphisms were not major determinants of telomere length or ACS risk in Czech females.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT14008" target="_blank" >NT14008: The influence of menopause on the development of cardiometabolic risk and signs of vascular damage - longitudinal study.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinica chimica acta
ISSN
0009-8981
e-ISSN
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Volume of the periodical
454
Issue of the periodical within the volume
February 15
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
4
Pages from-to
62-65
UT code for WoS article
000370305800012
EID of the result in the Scopus database
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