Posttransplant complications and genetic loci involved in telomere maintenance in heart transplant patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083484" target="_blank" >RIV/00023001:_____/22:00083484 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/22:10450142

Result on the web

<a href="https://www.mdpi.com/2073-4425/13/10/1855" target="_blank" >https://www.mdpi.com/2073-4425/13/10/1855</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/genes13101855" target="_blank" >10.3390/genes13101855</a>

Result language

angličtina

Original language name

Posttransplant complications and genetic loci involved in telomere maintenance in heart transplant patients

Original language description

Reaching critically short telomeres induces cellular senescence and ultimately cell death. Cellular senescence contributes to the loss of tissue function. We aimed to determine the association between variants within genes involved in telomere length maintenance, posttransplant events, and aortic telomere length in heart transplant patients. DNA was isolated from paired aortic samples of 383 heart recipients (age 50.7 +/- 11.9 years) and corresponding donors (age 38.7 +/- 12.0 years). Variants within the TERC (rs12696304), TERF2IP (rs3784929 and rs8053257), and OBCF1 (rs4387287) genes were genotyped, and telomere length was measured using qPCR. We identified similar frequencies of genotypes in heart donors and recipients. Antibody-mediated rejection (AMR) was more common (p &lt; 0.05) in carriers of at least one G allele within the TERF2IP locus (rs3784929). Chronic graft dysfunction (CGD) was associated with the TERC (rs12696304) GG donor genotype (p = 0.05). The genetic risk score did not determine posttransplant complication risk prediction. No associations between the analyzed polymorphisms and telomere length were detected in either donor or recipient DNA. In conclusion, possible associations between donor TERF2IP (rs3784929) and AMR and between TERC (rs12696304) and CGD were found. SNPs within the examined genes were not associated with telomere length in transplanted patients.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

<a href="/en/project/NU20-06-00061" target="_blank" >NU20-06-00061: The possibility of using free circulating gDNA and mtDNA in the detection of graft rejection after heart transplantation.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Genes

ISSN

2073-4425

e-ISSN

2073-4425

Volume of the periodical

13

Issue of the periodical within the volume

10

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

"art. no. 1855"

UT code for WoS article

000873003300001

EID of the result in the Scopus database

2-s2.0-85140712173