Association between aortic telomere length and cardiac post-transplant allograft function

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078040" target="_blank" >RIV/00023001:_____/19:00078040 - isvavai.cz</a>

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S0167527318356419?token=AF5168725DA3278634727469DE27A2207607D98B1987F57A5BE3504BEC91A4745B6AD9CADABA396479342EC8848EA7A6" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0167527318356419?token=AF5168725DA3278634727469DE27A2207607D98B1987F57A5BE3504BEC91A4745B6AD9CADABA396479342EC8848EA7A6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2019.05.006" target="_blank" >10.1016/j.ijcard.2019.05.006</a>

Result language

angličtina

Original language name

Association between aortic telomere length and cardiac post-transplant allograft function

Original language description

Background: In patients having undergone orthotopic heart transplantation, a number of complications exist that are known to be connected to both telomerase activity and telomere length. The aim of this study was to determine how telomere length in aortic DNA correlates with the subsequent post-transplantation development of the patients. Materials and methods: Between 2005 and 2015, we collected aortic samples from 376 heart recipients (age 50.8 +/- 11.8 years) and 383 donors (age 38.6 +/- 12.2 years). Relative telomere length in aortic tissue DNA was determined using quantitative PCR. Results: Shorter telomere length was detected in heart allograft recipients compared to donors (P &lt; 0.0001). Patients suffering acute cellular rejection had significantly shorter telomere length (P &lt; 0.01) than patients without rejection. Shorter telomere length was observed in patients with implanted mechanical circulatory support before heart transplantation (P &lt; 0.03), as well as in subjects with cardiac allograft vasculopathy (P &lt; 0.05). Overall survival time after heart transplantation was associated with shorter donor telomeres (P &lt; 0.004). Conclusions: Telomere length differed between donors and recipients independent of the sex and age of the patients. Our findings suggest a potential new linkage between the aortic telomere length of recipients and post-heart transplant complications. Further studies focusing on epigenetic modifications and gene regulation involved in telomere maintenance in transplanted patients should verify our results. (C) 2019 Elsevier B.V. All rights reserved.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of cardiology

ISSN

0167-5273

e-ISSN

—

Volume of the periodical

290

Issue of the periodical within the volume

September 1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

5

Pages from-to

129-133

UT code for WoS article

000470826500025

EID of the result in the Scopus database

2-s2.0-85065561674