Comparison of relative telomere length measured in aortic tissue and leukocytes in patients with end stage heart failure

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060070" target="_blank" >RIV/00023001:_____/16:00060070 - isvavai.cz</a>

Result on the web

<a href="http://www.nel.edu/archive_issues/37_2.htm" target="_blank" >http://www.nel.edu/archive_issues/37_2.htm</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Comparison of relative telomere length measured in aortic tissue and leukocytes in patients with end stage heart failure

Original language description

OBJECTIVES: Telomeres are repetitive non-coding DNA sequences on the ends of eukaryotic chromosomes. Relative leukocyte telomere length (LrTL) is considered to reflect biological ageing and fitness. Therefore, we examined whether LrTL would reflect rTL in aortic tissue (ArTL) and whether it could be used as a marker of biological heart age. DESIGN: We analysed telomere length in aortic and leukocyte samples from 73 heart recipients (63 males, 10 females; age 52.2+-11.7 years). Relative telomere length was measured using a quantitative PCR-based method. RESULTS: Neither LrTL nor ArTL correlated significantly with the age of heart recipients. Mean ArTL was slightly shorter than LrTL (p=0.06) and there was a slight but significant inverse correlation between LrTL and ArTL (p=0.019). CONCLUSIONS: The age of patients with end stage heart failure was not associated with leukocyte or aortic telomere length. An inverse correlation between LrTL and ArTL suggests that LrTL is unlikely to be an important predictor of biological ageing in these patients.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

—

Project

<a href="/en/project/NT14023" target="_blank" >NT14023: Analysis of telomere length as a potential predictive factor of successful heart transplant.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology letters

ISSN

0172-780X

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

2

Country of publishing house

SE - SWEDEN

Number of pages

5

Pages from-to

124-128

UT code for WoS article

000391807100007

EID of the result in the Scopus database

—