The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077473" target="_blank" >RIV/00023001:_____/18:00077473 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/ctr.13443" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/ctr.13443</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ctr.13443" target="_blank" >10.1111/ctr.13443</a>
Alternative languages
Result language
angličtina
Original language name
The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients
Original language description
Heart transplantation is a relatively common treatment for end-stage heart failure. The major complication of heart transplantation is organ rejection. Epigenetic could play a role in the pathogenesis of organ rejection, and the FTO gene is a mediator of DNA methylation. We analyzed a tagging FTO SNP rs17817449 in both donor and recipient DNA obtained through 370 heart transplantations. Recipient FTO genotypes were not associated with either type of rejection or with the general increase in the risk of rejection. When compared with patients without a history of rejection, carriers of transplanted hearts with the FTO TT genotype exhibited a significantly increased risk (P = 0.02) of suffering from both types of rejection in comparison to carriers of hearts with at least one G allele (OR; 95% CI = 2.56; 1.15-5.69). Our results suggest that the donor, but not the recipient, FTO genotype could be a significant predictor of acute rejection in heart transplant patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30213 - Transplantation
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical transplantation
ISSN
0902-0063
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
"art. no. e13443"
UT code for WoS article
000454089700015
EID of the result in the Scopus database
2-s2.0-85056876845