B-type natriuretic peptide: powerful predictor of end-stage chronic heart failure in individuals with systolic dysfunction of the systemic right ventricle

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059977" target="_blank" >RIV/00023001:_____/16:00059977 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/16:N0000076

Result on the web

<a href="http://www.cmj.hr/default.aspx?id=12673&issue=yes" target="_blank" >http://www.cmj.hr/default.aspx?id=12673&issue=yes</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3325/cmj.2016.57.343" target="_blank" >10.3325/cmj.2016.57.343</a>

Result language

angličtina

Original language name

B-type natriuretic peptide: powerful predictor of end-stage chronic heart failure in individuals with systolic dysfunction of the systemic right ventricle

Original language description

Aim: To assess whether B-type natriuretic peptide (BNP) can serve as a predictor of end-stage chronic heart failure (CHF) in patients with severe systolic dysfunction of the systemic right ventricle (SRV). Methods: We performed a retrospective analysis in 28 patients with severe systolic dysfunction of the SRV (ejection fraction 23 +- 6%) who were evaluated as heart transplant (HTx) candidates between May 2007 and October 2014. The primary endpoints of the study (end-stage CHF) were progressive CHF, urgent HTx, and ventricular assist device (VAD) implantation. Plasma BNP levels were measured using a chemiluminescent immunoassay. Results: During median follow-up of 29 months (interquartile range, 9-50), 3 patients died of progressive CHF, 5 patients required an urgent HTx, and 6 patients underwent VAD implantation. BNP was a strong predictor of end-stage CHF (hazard ratio per 100 ng/L: 1.079, 95% confidence interval, 1.042-1.117, P<0.001). The following variables with corresponding areas under the curve (AUC) were identified as the most significant predictors of end-stage CHF: BNP (AUC 1.00), New York Heart Association functional class class III or IV (AUC 0.98), decompensated CHF in the last year (AUC 0.96), and systolic dysfunction of the subpulmonal ventricle (AUC 0.96). Conclusion: BNP is a powerful predictor of end-stage CHF in individuals with systolic dysfunction of the SRV.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/NV15-27682A" target="_blank" >NV15-27682A: Next generation sequencing for early diagnosis and individualized treatment of dilated cardiomyopathy and related forms of cardiomyopathy</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Croatian medical journal

ISSN

0353-9504

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

4

Country of publishing house

HR - CROATIA

Number of pages

8

Pages from-to

343-350

UT code for WoS article

000384783200005

EID of the result in the Scopus database

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