Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060011" target="_blank" >RIV/00023001:_____/16:00060011 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S0378111916306163/1-s2.0-S0378111916306163-main.pdf?_tid=66e0d1cc-96c8-11e6-9e96-00000aab0f26&acdnat=1476969994_67b520003b2173d767172c1dfa7b54a2" target="_blank" >http://ac.els-cdn.com/S0378111916306163/1-s2.0-S0378111916306163-main.pdf?_tid=66e0d1cc-96c8-11e6-9e96-00000aab0f26&acdnat=1476969994_67b520003b2173d767172c1dfa7b54a2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.gene.2016.07.070" target="_blank" >10.1016/j.gene.2016.07.070</a>
Alternative languages
Result language
angličtina
Original language name
Apolipoprotein A5 fifteen years anniversary: Lessons from genetic epidemiology
Original language description
Apolipoprotein A5 (APOA5) is a small protein, expressed predominantly in the liver. In plasma, it is located on triglyceride rich lipoprotein particles (chylomicrones and VLDL) and on HDL Plasma concentration of apolipoprotein A5 is very low, suggesting rather regulatory (activation of lipoprotein lipase, ... ) than structural function. APOA5 is an important determinant of plasma triglyceride concentration; this effect has been confirmed both on animal models, as well as on human studies. Minor alleles of three commonly analysed variants within this gene (rs662799, rs3135506, rs2075291) are associated with higher plasma TG values and increased risk of myocardial infarction, with some important interethnic differences observed. Further roles of APOA5; determination of BMI, diabetes and last but not least nutri- and pharmaco-genetic interactions are suggested, but without the definitive conclusions.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gene
ISSN
0378-1119
e-ISSN
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Volume of the periodical
592
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
193-199
UT code for WoS article
000383304600025
EID of the result in the Scopus database
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