Circulating microparticles as a predictor of vascular properties in patients on mechanical circulatory support; hype or hope?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060058" target="_blank" >RIV/00023001:_____/16:00060058 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/16:10330263 RIV/00216208:11120/16:43912262

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/65/65_727.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/65/65_727.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Circulating microparticles as a predictor of vascular properties in patients on mechanical circulatory support; hype or hope?

Original language description

Microparticles are small circulating vesicles originating from circulatory system and vascular wall cells released during their activation or damage. They possess different roles in regulation of endothelial function, inflammation, thrombosis, angiogenesis, and in general, cellular stress. Microparticles are the subject of intensive research in pulmonary hypertension, atherosclerotic disease, and heart failure. Another recently emerging role is the evaluation of the status of vasculature in end-stage heart failure patients treated with implantable ventricular assist devices. In patients implanted as destination therapy, assessment of the long-term effect of currently used continuous-flow left ventricular assist devices (LVADs) on vasculature might be of critical importance. However, unique continuous flow pattern generated by LVADs makes it difficult to assess reliably the vascular function with most currently used methods, based mainly on ultrasound detection of changes of arterial dilatation during pulsatile flow. In this respect, the measurement of circulating microparticles as a marker of vascular status may help to elucidate both short- and long-term effects of LVADs on the vascular system. Because data regarding this topic are very limited, this review is focused on the advantages and caveats of the circulating microparticles as markers of vascular function in patients on continuous-flow LVADs.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/NT14019" target="_blank" >NT14019: The Impact of Pulsatile Blood Flow on the Vascular Damage in Patients with Mechanical Ventricular Assist Devices.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

5

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

727-735

UT code for WoS article

000389223400002

EID of the result in the Scopus database

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