Endothelial Dysfunction Expressed as Endothelial Microparticles in Patients With End-Stage Heart Failure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061370" target="_blank" >RIV/00159816:_____/14:00061370 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/14:43909173 RIV/00023001:_____/14:00059111
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Endothelial Dysfunction Expressed as Endothelial Microparticles in Patients With End-Stage Heart Failure
Original language description
Left ventricular assist devices (LVAD), currently used in treatment of terminal heart failure, are working on principle of rotary pump, which generates continuous blood flow. Non-pulsatile flow is supposed to expose endothelial cells to high stress and potential damage. Therefore, we investigated longitudinal changes in concentration of circulating endothelial microparticles (EMP) as a possible marker of endothelial damage before and after implantation of LVAD. Study population comprised 30 patients with end-stage heart failure indicated for implantation of the Heart Mate II LVAD. Concentrations of microparticles were measured as nanomoles per liter relative to phosphatidylserine before and 3 months after implantation. At 3 months after implantation weobserved significant decrease in concentration of EMP [5.89 (95 % CI 4.31-8.03) vs. 3.69 (95 % CI 2.70-5.03), p= 0.03] in the whole group; there was no difference observed between patients with ischemic etiology of heart failure (n= 18)
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Research
ISSN
0862-8408
e-ISSN
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Volume of the periodical
63
Issue of the periodical within the volume
S3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
"S369"-"S373"
UT code for WoS article
000345591100007
EID of the result in the Scopus database
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