Inhaled sodium nitrite improves rest and exercise hemodynamics in heart failure with preserved ejection fraction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060150" target="_blank" >RIV/00023001:_____/16:00060150 - isvavai.cz</a>

Result on the web

<a href="http://circres.ahajournals.org/content/119/7/880" target="_blank" >http://circres.ahajournals.org/content/119/7/880</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/CIRCRESAHA.116.309184" target="_blank" >10.1161/CIRCRESAHA.116.309184</a>

Result language

angličtina

Original language name

Inhaled sodium nitrite improves rest and exercise hemodynamics in heart failure with preserved ejection fraction

Original language description

Rationale: Abnormalities in nitric oxide signaling play a pivotal role in heart failure with preserved ejection fraction (HFpEF). Intravenous sodium nitrite, which is converted to nitric oxide in vivo, improves hemodynamics in HFpEF, but its use is limited by the need for parenteral administration. Nitrite can also be administered using a novel, portable micronebulizer system suitable for chronic use. Objective: Determine whether inhaled nitrite improves hemodynamics in HFpEF. Methods and Results: In a double-blind, randomized, placebo-controlled, parallel-group trial, subjects with HFpEF (n=2 (6)) underwent cardiac catheterization with simultaneous expired gas analysis at rest and during exercise before and after treatment with inhaled sodium nitrite (90 mg) or placebo. The primary end point was the pulmonary capillary wedge pressure during exercise. Before study drug administration, HFpEF subjects displayed an increase in pulmonary capillary wedge pressure with exercise from 20 +/- 6 to 34 +/- 7 mm Hg (P<0.0001). After study drug administration, exercise pulmonary capillary wedge pressure was substantially improved by nitrite as compared with placebo (baseline-adjusted mean 25 +/- 5 versus 31 +/- 6 mm Hg; analysis of covariance P=0.022). Inhaled nitrite reduced resting pulmonary capillary wedge pressure (-4 +/- 3 versus -1 +/- 2 mm Hg; P=0.002), improved pulmonary artery compliance (+1.5 +/- 1.1 versus +0.6 +/- 0.9 mL/mm Hg), and decreased mean pulmonary artery pressures at rest (-7 +/- 4 versus -3 +/- 4 mm Hg; P=0.007) and with exercise (-10 +/- 6 versus -5 +/- 6 mm Hg; P=0.05). Nitrite reduced right atrial pressures, with no effect on cardiac output or stroke volume. Conclusions: Acute administration of inhaled sodium nitrite reduces biventricular filling pressures and pulmonary artery pressures at rest and during exercise in HFpEF. Further study is warranted to evaluate chronic effects of inhaled nitrite in HFpEF.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Circulation research

ISSN

0009-7330

e-ISSN

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Volume of the periodical

119

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

880-886

UT code for WoS article

000384001200016

EID of the result in the Scopus database

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