Arterials stiffening with exercise in patients with heart failure and preserved ejection fraction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F17%3A00075941" target="_blank" >RIV/00023001:_____/17:00075941 - isvavai.cz</a>
Result on the web
<a href="http://ac.els-cdn.com/S0735109717374223/1-s2.0-S0735109717374223-main.pdf?_tid=7def7772-994e-11e7-bbc9-00000aacb360&acdnat=1505394986_136cd7547d81d4d89749e1d73d0b9904" target="_blank" >http://ac.els-cdn.com/S0735109717374223/1-s2.0-S0735109717374223-main.pdf?_tid=7def7772-994e-11e7-bbc9-00000aacb360&acdnat=1505394986_136cd7547d81d4d89749e1d73d0b9904</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jacc.2017.05.029" target="_blank" >10.1016/j.jacc.2017.05.029</a>
Alternative languages
Result language
angličtina
Original language name
Arterials stiffening with exercise in patients with heart failure and preserved ejection fraction
Original language description
BACKGROUND Aortic stiffening and reduced nitric oxide (NO) availability may contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF). OBJECTIVES This study compared indices of arterial stiffness at rest and during exercise in subjects with HFpEF and hypertensive control subjects to examine their relationships to cardiac hemodynamics and determine whether exertional arterial stiffening can be mitigated by inorganic nitrite. METHODS A total of 22 hypertensive control subjects and 98 HFpEF subjects underwent hemodynamic exercise testing with simultaneous expired gas analysis to measure oxygen consumption. Invasively measured radial artery pressure waveforms were converted to central aortic waveforms by transfer function to assess integrated measures of pulsatile aortic load, including arterial compliance, resistance, elastance, and wave reflection. CONCLUSIONS Abnormal pulsatile aortic loading during exercise occurs in HFpEF independent of hypertension and is correlated with classical hemodynamic derangements that develop with stress. Inorganic nitrite mitigates arterial stiffening with exercise and improves hemodynamics, indicating that arterial stiffening with exercise is at least partially reversible. Further study is required to test effects of agents that target the NO pathway in reducing arterial stiffness in HFpEF. (Study of Exercise and Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease [EXEC]; NCT01418248. Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction; NCT01932606. Inhaled Sodium Nitrite on Heart Failure With Preserved Ejection Fraction; NCT02262078) (C) 2017 by the American College of Cardiology Foundation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the American College of Cardiology
ISSN
0735-1097
e-ISSN
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Volume of the periodical
70
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
136-148
UT code for WoS article
000404540800003
EID of the result in the Scopus database
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