Sedative effects of intranasal oxytocin in rabbits and rhesus monkeys

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00060239" target="_blank" >RIV/00023001:_____/16:00060239 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/16:43912634 RIV/00064173:_____/16:N0000125
Result on the web
<a href="http://www.biomed.cas.cz/physiolres/pdf/65/65_S473.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/65/65_S473.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Sedative effects of intranasal oxytocin in rabbits and rhesus monkeys
Original language description
Oxytocin is a hormone therapeutically used mainly for its peripheral effects during pregnancy in the uterus and breasts. However, additional central effects, i.e. anxiolytic effect, decreased level of social stress and increased empathy have been also observed. Hence, the aim of our study was to evaluate if nasal oxytocin can be used as anxiolytic substance in rhesus monkeys (n = 20) and rabbits (n = 20). Simultaneously, mean arterial blood pressure, arterial oxygen saturation of hemoglobin and pulse rate were monitored in all the evaluated animals. While rabbits lost righting reflex, monkeys developed a dose-dependent loss of aggressiveness and/or anxiety as evaluated by behavioral methods (aggressive behavior was classified as non-sedated. sedated - strongly sedated).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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